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13a, Supplementary Table 9), suggesting that the distinct rotamer orientation of H296 ECL2 in Cagri-bound CTR (to accommodate the Glu linker) and/or the observed more open ECL3 conformation induced by the lipidated peptide may facilitate or stabilize an active CTR conformation (Supplementary Fig

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These targets contain a range of crucial factors, such as PDZ proteins that manage cell signaling and adhesion, the p300/CBP transcriptional activators that participate in differentiation regulation and cell cycle control, as well as proteins involved in apoptosis [23]

Tsai P-H, Liu J-J, Yeh C-L, Chiu W-C, Yeh S-L

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